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Monday, August 5, 2013
AOC?s latest USB monitor offers faster performance in a thinner package
When I downsized from a 27″ iMac to a 13″ Macbook Air for my main computer, It felt liberating being able to carry around my computer anywhere I needed to go. But giving up a huge display for one much smaller did take some adjustment. When I’m couch surfing, I don’t really mind the smaller […]
Did Raven-Symone out herself with a Tweet?
Celebs 
7 hours ago
Has former "Cosby Show" and "That's So Raven" star Raven-Symone outed herself with a single Tweet? Here's the comment in question, which was posted on Friday:
Last year, the National Enquirer wrote a story indicating she was living with former "America's Top Model" contestant AzMarie Livingston. At the time, she tweeted, "My sexual orientation is mine, and the person I'm dating to know. I'm not one for a public display of my life."
In a statement to E! News after her most recent Tweet, however, she said, "I am very happy that gay marriage is opening up around the country and is being accepted. I was excited to hear today that more states legalized gay marriage. I, however am not currently getting married, but it is great to know I can now, should I wish to."
The actress, who got her start in 1989 at age 3 on "The Cosby Show" as Olivia Kendall, has worked steadily since. She debuted on Broadway in 2012 as the lead in "Sister Act."
Her over 482,000 followers on Twitter have largely been supportive; one asked, "Can I have your spot in the Cheetah Girls? Disney might not like you anymore."
Source: http://www.today.com/entertainment/did-raven-symone-out-herself-tweet-6C10839618
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Egyptian Brotherhood leaders to face trial for inciting murder
CAIRO (Reuters) - The leader of Egypt's Muslim Brotherhood and his deputy will face trial in three weeks' time for crimes including incitement to murder during protests in the days before the overthrow of President Mohamed Mursi, a Cairo court announced on Sunday.
The move showed the army-backed interim government was pushing ahead with a crackdown against the Muslim Brotherhood, to which Mursi belongs, while international envoys try to help resolve the political crisis brought on by his removal by the army on July 3.
State news agency MENA quoted the court as saying it would start the trial of Mohamed Badie and his deputy Khairat el-Shater on August 25.
The general prosecutor also ordered the pre-trial detention for 15 days of Rifaa El-Tahtawy, Mursi's former chief-of-staff, and his deputy, who are accused of inciting the detention, torture and interrogation of protesters in 2012, MENA reported.
Mursi's allies view them as political detainees who should be included in talks to ease tensions.
Badie, who is not in custody, Shater and Rashad al-Bayoumi, another Brotherhood leader, are due to be tried alongside three others accused of killing at least two men in violence around the group's Cairo headquarters on June 30.
Arrested warrants were issued for Shater and Badie on July 4 on accusations of inciting the violence in which at least eight people were killed on a night of mass protests against Mursi.
Shater, a businessman seen as the Brotherhood's leading political strategist, had been the Islamist group's first choice candidate to run in last year's presidential election. But he was disqualified due to past convictions, forcing Mursi to take his place.
Bayoumi is being held in Torah prison on the outskirts of Cairo, the same place where former strongman Hosni Mubarak, who was toppled by a popular uprising in February 2011, and his sons Alaa and Gamal are detained.
Mursi, who has also been accused of murder and other crimes, is detained at an undisclosed location.
(Reporting By Shadia Nasralla; Editing by Angus MacSwan and Robin Pomeroy)
Source: http://news.yahoo.com/egyptian-brotherhood-leaders-face-trial-inciting-murder-170422992.html
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Sunday, August 4, 2013
7 Most Desirable Jobs on Earth
Bangalore: Most people just work to earn a living, while a lucky few land a job that is in line with their passion. But the most fortunate individuals on earth are those who have a job that we all envy.
Take a look at some of the most desirable jobs that are not typical, but are high on excitement, pay and fun, as listed by Jermaine Taylor for CNBC and other sources.
Bike Rider-Photographer for Google Maps
This is the coolest and the most desirable job on the list. All you need to do in this job is ride a three-wheeler that is fitted with 9 cameras, a GPS, a computer and a generator, and go on a field trip visiting historical sites or monuments that are inaccessible by car, which most of us are willing to do it for free.
Read More:
5 Jobs That You Can Opt for At Any Point in Your Career
Top Jobs for Your Golden Years
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Lohan makes fun of herself on 'Chelsea Lately'
TV 
6 hours ago
Michael Buckner / Getty Images file
Actress Lindsay Lohan will guest host the Aug. 5 episode of "Chelsea Lately."
Look out, Chelsea Handler! Lindsay Lohan might be coming for your job.
A vibrant-looking Lohan, fresh off a 90-day court-ordered stint in rehab, filled in for Handler as host of "Chelsea Lately" on Thursday. Although the episode isn't scheduled to air until Aug. 5, from the sneak peek clips provided, it looks like LiLo took the opportunity to poke fun at herself ? and fellow actress Kristen Stewart ? during her guest spot.
During the episode's round-table discussion, Lohan garnered laughs from the crowd and other hosts when, while?reporting on a story?that One Direction member Harry Styles is possibly bisexual and dating a DJ named Nick, she deadpanned, "I've been there!" (Lohan dated DJ Samantha Ronson in 2008.)?
Lohan also used the opportunity to take a jab at Stewart, who recently made headlines for cursing out a group of paparazzi photographers.?
"I'm just excited that Kristen Stewart, you know, finally showed some emotion,"?Lohan said?of the famously indifferent "Twilight" actress.
Her joke garnered a roar of laughter from the audience, and even prompted comedian Fortune Feimster, who was part of the round table, to suggest that her comment may start an alley fight between the troubled actress and the "Twilight" star.
"No, I love her. I'm a Kristen Stewart fan," Lohan insisted before continuing to poke fun at the actress' 2012 cheating scandal with "Snow White" director Rupert Sanders.
Lohan hosts Chelsea Lately on Aug. 5 at 11 p.m. on E!
Source: http://www.today.com/entertainment/lindsay-lohan-makes-fun-herself-chelsea-lately-6C10831619
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Wednesday, July 31, 2013
Indonesia promises not to snoop on foreign leaders: media
JAKARTA (Reuters) - Indonesia pledged not to eavesdrop on foreign leaders when it hosts a major summit later this year despite irritation over reports that its own leader was spied on when he was overseas.
Classified documents leaked last month by whistleblower Edward Snowden showed British intelligence services had used "groundbreaking intelligence capabilities" to monitor the communications of visiting world leaders at the G-20 summit in 2009, according to The Guardian daily. Indonesian President Susilo Bambang Yudhoyono attended that gathering.
The Sydney Morning Herald reported last week that the Australian government was among those which made use of the British intelligence on Yudhoyono and other Asian leaders.
"We must give a guarantee that such practices will not happen here in Indonesia, especially during the (upcoming) APEC summit in Bali," Marciano Norman, head of the state intelligence agency, was quoted as saying on Tuesday by the Jakarta Post daily.
The Asia-Pacific Economic Cooperation (APEC) has 21 members including the United States, China and Russia. Britain is not a member.
"Indonesia has never had a practice of spying on visiting foreign delegates. If there's any truth to the news reports, then what the UK did is for sure completely unethical," Teuku Faizasyah, presidential spokesperson for foreign affairs, told Reuters.
"You're hosting foreign dignitaries and there should be some respect for their privacy."
(Reporting by Kanupriya Kapoor, editing by Jonathan Thatcher and Ron Popeski)
Source: http://news.yahoo.com/indonesia-promises-not-snoop-foreign-leaders-media-094820500.html
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Smart Cargo for iPad review
I have completely replaced a laptop in my life with my iPad. I discovered this about a year into having my first iPad, when I realized the only time I had moved my MacBook Pro from the desk was when I presented, using both it and my iPad at a few meetings. But, when I’m [...]
Source: http://the-gadgeteer.com/2013/07/29/smart-cargo-for-ipad-review/
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Tuesday, July 30, 2013
UBS to repay Swiss bailout loan, cautious on third-quarter
By Katharina Bart
ZURICH (Reuters) - UBS
The move draws a line under the Swiss government's rescue of UBS nearly five years after the bank threatened to collapse under the weight of more than $50 billion in losses on mortgage securities.
"The results show that our strategy is right and we're ahead on execution," UBS's Chief Executive Sergio Ermotti said in a statement.
UBS's shares hit a two-year high last week after the bank disclosed a quarterly profit that beat analyst views, even after paying $885 million to settle a lawsuit with the U.S. housing regulator over the mis-selling of mortgage-backed bonds.
In its outlook on Tuesday, UBS said third-quarter revenue and net new money -- a closely-watched bellwether of future business -- may be hit as clients fret about the euro zone, U.S. debt trouble, as well as the mixed global economic outlook.
"Nevertheless, we remain confident that our wealth management businesses will continue to attract new money," UBS said in a statement. The flagship private bank took in 10.1 billion francs of fresh money this quarter.
Profit at UBS's investment bank rose amid buoyant markets for equities -- a traditional strength.
DIVIDEND IMPACT
UBS will buy the bailout fund back from Switzerland's central bank later this year. It can purchase it for $1 billion plus 50 percent of its gains. The move will add up to 90 basis points to UBS's capital ratios, by taking on the cash and securities remaining after the loan is repaid.
Analysts including Morgan Stanley and Espirito Santo had said previously that UBS could use a such a buyback to fuel dividends. On Tuesday, UBS didn't comment on the effect the repurchase will have on its shareholder payout policy.
The government took a nine percent stake in UBS as part of the bailout, which saw UBS receive a 6-billion-Swiss-franc shot in the arm. Switzerland sold the stake less than a year later at a 1.2 billion franc profit.
However, roughly $38.7 billion in toxic former UBS assets were tricker to handle. Offloaded to a fund managed by the Swiss National Bank as part of the bailout, the central bank has been selling them down since.
The outstanding loan for the fund, which added 316 million Swiss francs to the central bank's first-half results, was lowered dramatically in the period to 1.2 billion, the SNB said in a statement.
(This story was refiled to fix typo in headline)
(Reporting By Katharina Bart: Editing by Carmel Crimmins)
Source: http://news.yahoo.com/ubs-repays-swiss-bailout-loan-buys-back-assets-045917810.html
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Monday, July 29, 2013
The Staycation in Park Royal Penang - Places and Foods, Travel ...
28 July 2013 145 views No Comment
The Staycation in Park Royal Penang
When you mentioned Park Royal Penang in Batu Ferringhi, many will tell you stories on the history of the hotel. While many locals still live in the past, the hotel has move on. In fact, the hotel has gone through a revamp with a huge renovation on their hotel rooms. The legacy remains with new directions.
Penang has changed for good in the past few years. More places for good food and more hotels are opening on the island. To drive from Kuala Lumpur to Penang, it should take less than five hours drive (without speeding) with leisure speed and it will take an hour for a plane ride. We chose to drive because we wanted to travel freely on the island.
It didn?t take us long to reach Park Royal Hotel. Even though the exterior looks the same but the interior is a world of its own. I always feel that hotel services in Malaysia fares poorer compare to our neighbours but in Park Royal Penang they proved me wrong. Doormen and front desk staffs were helpful and friendly.
We got ourselves a beautiful seaview room. I love how the newly renovated hotel rooms. It looks like new!
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The swimming pools in Park Royal Penang must be mentioned. They have two swimming pools, one for the adults and one for the children.
If you are bringing your kids for a staycation in Park Royal, they will love the children?s pool. It is like mini water theme park but it is always advisable parents or guardians should be around when the kids are playing in the pool
If you are a beach person, just walk a few steps and you will be greeted by the beautiful Batu Ferrighi white sandy beach. Facing the Strait of Malacca, there are varieties of sports activities available.
Having a brisk walk or even a jog at this beautiful beach during morning or evening is relaxing. Usually the sea water here is not that rough so swimming in the sea is consider safe. Jelly fish attacks are rare in Penang.
If you don?t want to soak into the sea water, you can always sun bathing at the benches available exclusive for hotel guests.
Breakfast in Parkroyal Penang was not disappointing as well. I thought it will be the same old typical ?Malaysia hotel breakfast? and I was wrong. They have local Penang food like char kuey teow and nasi lemak for breakfast.
I stayed two nights in Parkroyal Penang and it was blissful. Due to Rachel?s pregnancy, we stayed in the hotel most of the time and we didn?t even make time for the Batu Ferringhi night market. Please don?t be fooled by the exterior and the history of the hotel as the rooms were renovated and rejuvenated. If you are planning to visit Penang for a staycation, ParkRoyal Penang Batu Ferringhi is an option for you.
Park Royal Penang ?Address:
Batu Ferringhi Beach, 11100 Batu Ferringhi, Penang, Malaysia
Phone: +60 4-881 1133
Website: http://www.parkroyalhotels.com/en/hotels/malaysia/penang/parkroyal/location/index.html
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Popularity: 1% [?]
Source: http://www.placesandfoods.com/2013/07/the-staycation-in-park-royal-penang.html
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Novel mechanism that helps stomach bug cause illness identified
[unable to retrieve full-text content]A seafood contaminant that thrives in brackish water during the summer works like a spy to infiltrate cells and quickly open communication channels to sicken the host, researchers report.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Toa6ud_fdQo/130728133904.htm
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Sunday, July 28, 2013
3 dead when bus carrying teens from church camp crashes on busy thoroughfare in Indianapolis
INDIANAPOLIS - The Indianapolis Fire Department says three people were killed when a bus carrying teens from a church camp crashed on a busy thoroughfare near Interstate 465.
The bus was carrying 40 passengers who are members of Colonial Hill Baptist Church and were returning from camp when the crash happened Saturday afternoon.
Indianapolis Fire Department spokesman Lt. Rita Burris confirms the deaths and says survivors were being taken to area hospitals. Those injured include children and adults.
Some of the victims were taken from the scene by helicopter.
An Indiana Department of Transportation camera showed the bus overturned on its side.
Roads near the scene were closed, and hazmat crews were in the area cleaning up diesel fuel that spilled.
Source: http://news.yahoo.com/3-dead-bus-carrying-teens-church-camp-crashes-214252223.html
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Monday, July 15, 2013
S&P 500 gains for an eighth day, buoyed by Citigroup
By Caroline Valetkevitch
NEW YORK (Reuters) - Citigroup's solid earnings helped the S&P 500 end higher on Monday for an eighth straight day, the longest such streak since mid-January, though weak retail sales curbed the advance.
The Dow Jones industrial average and the S&P 500 finished at record closing highs for the third consecutive session. The Nasdaq scored its highest close since September 2000.
Volume was the lowest of any full trading day this year, with just 4.89 billion shares trading on exchanges, based on the latest available data. This year, daily volume has averaged 6.4 billion shares on the New York Stock Exchange, the Nasdaq and the NYSE MKT.
Shares of Citigroup (NYS:C) climbed 2 percent to $51.81 after the third-largest U.S. bank by assets reported a 26 percent increase in adjusted quarterly profit. The S&P 500 financial industry sector index (CME:^SPSY) gained 0.4 percent.
Leap Wireless International Inc (LEAP) shares more than doubled after AT&T Inc (NYS:T) said late Friday it would buy the company for $1.19 billion and at least two brokerages raised their ratings on Leap's stock. Leap, which was among the Nasdaq's most-active stocks, ended at $16.95 - up 112.41 percent.
The day's economic data was mixed, however, with growth in New York state manufacturing for July accelerating, while June retail sales fell short of expectations. May business inventories barely increased.
Investors are watching for changes in earnings or economic news that could derail the market's rally. Stocks have climbed this year, except for a late-May selloff triggered by Federal Reserve Chairman Ben Bernanke's comments, which raised the prospect of trimming the Fed's $85 billion in monthly stimulus. The S&P 500 has gained 18 percent since December 31.
Nicholas Colas, chief market strategist at the ConvergEx Group in New York, said the fact that Citigroup and other financial companies have done well this earnings season is a positive sign.
"We believe the economy is getting better, so they should be doing well. That's enough to offset retail sales data," Colas said.
The Dow Jones industrial average (^DJI) rose 19.96 points, or 0.13 percent, to 15,484.26, a record closing high. The Standard & Poor's 500 Index (^GSPC) gained 2.31 points, or 0.14 percent, to finish at 1,682.50, also a record. The Nasdaq Composite Index (^IXIC) advanced 7.41 points, or 0.21 percent, to end at 3,607.49 - its highest close since September 2000.
Much of the focus this week will be on earnings. Analysts expect S&P 500 companies' second-quarter earnings to have grown 2.8 percent from a year earlier, with revenue up 1.5 percent from a year ago, Thomson Reuters data showed.
While earnings growth has slowed in recent quarters, it is expected to pick up the last half of the year. Bank of America-Merrill Lynch raised its year-end target for the S&P 500 to 1,750 from 1,600, citing expected earnings growth.
Most companies also are exceeding analysts' earnings expectations, as they have done in recent quarters. Of the companies that have reported second-quarter results so far, 66.7 percent are beating earnings estimates. Revenue results are faring worse.
S&P 500 industrial shares rose after airlines expressed confidence over the weekend in the safety of Boeing's (BA) 787 Dreamliner following a fire on one of the jets last week. Boeing gained 3.7 percent to $105.66 and ranked as the Dow's top performer.
Utilities outperformed other sectors in the S&P 500, with the sector index (.SPLRCU) up 1.6 percent. Utility companies, including FirstEnergy Corp (FE) and Public Service Enterprise Group Inc (PEG), were among the sector's best performers after power grid operators in the U.S. Northeast said they had enough electricity to keep air conditioners running this week through an anticipated heat wave.
First Solar Inc (FSLR) was the S&P 500's best percentage gainer, rising 5.5 percent to $50.27.
Shares of Tiffany & Co (TIF.N) jumped 3.6 percent to $79.78 in active trading after Stifel Nicolaus upgraded the high-end jeweler's stock to a "buy" from a "hold" and set a price target of $92.
On the flip side, shares of Ingredion (INGR.N) dropped 9.9 percent to $62.57, a day after the company warned on earnings.
Advancers outnumbered decliners on the New York Stock Exchange by a ratio of about 19 to 11, while on the Nasdaq, 16 stocks rose for nearly every nine that fell.
(Editing by Kenneth Barry, Nick Zieminski and Jan Paschal)
Source: http://news.yahoo.com/china-data-helps-futures-edge-112122651.html
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Sunday, June 30, 2013
Panel urges more scrutiny of US companies in Macau
HONG KONG (AP) ? Members of a congressional advisory panel believe U.S. regulators should tighten scrutiny of casino companies operating in Macau, the world's top gambling market, because of the risk of money laundering.
"We need to go deeper into this," said Michael Wessel, a member of the U.S.-China Economic and Security Review Commission, which heard testimony in Washington on Thursday.
"I'm not sure the companies are looking as deep as they need to in their own organizations and the profits are driving their activities. It's worth some stricter scrutiny."
The commission was set up in 2000 to examine national security implications of the trade and economic relationship between China and the U.S. and make recommendations to the U.S. Congress.
Nevada-based Las Vegas Sands Corp., Wynn Resorts Ltd. and MGM Resorts International are among six operators that have shared in the casino boom in Macau, the only place in China where gambling is legal. The former Portuguese colony earned $38 billion in gambling revenue last year, about six times more than the Las Vegas Strip.
Most of Macau's gambling revenue comes from the tens of millions of mainland Chinese gamblers who visit each year. However, the central government in Beijing imposes strict capital controls that limit the amount of money that can be taken out of mainland China to 20,000 yuan ($3,200) per trip.
To get around these controls, wealthy Chinese gamblers use so-called junket agents who arrange for them to travel to Macau, visit private VIP rooms, lend them money for their bets and collect on debts. VIP gamblers account for about two-thirds of Macau's total gambling revenue.
"The structure of the casino system in Macau effectively allows people to use the casinos to circumvent these capital controls," Commission Chairman William Reinsch said in opening remarks.
State and federal regulators want to make sure casino companies "do not get drawn into activities that would be considered illegal or improper in the United States," he said.
A.G. Burnett, chairman of the Nevada State Gaming Board, testified that it is "common knowledge that the operation of VIP rooms in Macau casinos had long been dominated by Asian organized crime, commonly referred to as triads."
He said the casinos themselves may not be aware of illegal transactions.
"Criminal transactions are widely alleged to take place just out of the direct purview of the casino," he said.
The commission's concerns come as Sands and Wynn face investigations from U.S. authorities over their activities in Macau. The two companies earn most of their profits from the tiny gambling enclave, an hour from Hong Kong by high-speed ferry.
Spokespeople for Sands' and Wynn's China units declined to comment. Macau's gambling regulator and a spokesperson for MGM China did not reply to a request for comment.
Burnett said that U.S. casino companies have strong compliance programs in Macau to make sure there are "no nefarious activities" in their operations. He said the influence of the junket operators in Macau may be waning and that the casinos may not have rely on them so much in the future to bring in wealthy gamblers.
When asked whether Nevada regulators had ever seen any organized crime at U.S. casinos in Macau, including at VIP rooms, or had taken any disciplinary action against a casino for violations there, he said they had not.
Burnett said that U.S. casinos had already suffered "to some extent" because they are required to cover the Nevada regulators expenses, including dispatching staff to Macau to meet their counterparts and check operations.
"Travel to China is not cheap," Burnett said. "We are routinely sending agents there now."
_____
Online:
Follow Kelvin Chan at twitter.com/chanman
Commission website: http://www.uscc.gov
Source: http://news.yahoo.com/panel-urges-more-scrutiny-us-companies-macau-073738549.html
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Saturday, June 29, 2013
Hookup Shocker: The Sex Is Legal, but Talking About It Is a Felony ...
This week the Ohio House of Representatives unanimously approved a bill ostensibly aimed at fighting "human trafficking" that makes it a crime to "solicit" a legal act: sex with someone who is 16 or 17 years old. The age of consent in Ohio is 16. Yet under H.B. 130, a 20-year-old who asks a 16-year-old to have sex with him, or a 21-year-old who does the same with a 17-year-old, thereby commits a fifth-degree felony, punishable by six to 12 months in jail and a $2,500 fine. He also has to register as a sex offender. But if the teenager broaches the subject, or if the sex proceeds without any explicit verbal reference to it, no crime has been committed. Here is the relevant provision:
No person shall solicit another, not the spouse of the offender, to engage in sexual conduct with the offender, when the offender is eighteen years of age or older and four or more years older than the other person,?and?the other person is sixteen or seventeen years of age,?whether or not?the offender knows?the age of the other person.
Since there is no requirement that money change hands, this provision criminalizes ordinary sexual propositions if one person is 16 or 17 and the other is at least four years older when it is the older person who makes the suggestion, even though the sex itself remains legal. Having sex is fine, as long as you don't talk about it beforehand.
The elimination of any knowledge requirement, which is problematic even when the "solicitation" involves someone below the age of consent, is especially so when the person approached is 16 or 17. Since the difference between a 16- or 17-year-old and an 18-year-old may be difficult to discern, someone keen to avoid a felony charge would be wise to demand proof of age before saying anything about sex. And if the object of his attention happens to have a fake ID?as teenagers pretending to be older than they are sometimes do, especially when they go to bars or clubs?that is no defense. As Granville, Ohio, attorney Drew Mc Farland notes, the bill imposes ?a "strict liability" sta ndard, meaning that "even an honest mistake is unforgiven." Mc Farland, who drew my attention to this bill, suggests one such scenario:
A mature 17-year-old is lawfully in a liquor-serving establishment and meets a 22-year-old who suggests they go back to his or her place for some sexual fun.?Under this change in the law, the 22-year-old is guilty of a felony.
Legislators already define "human trafficking" broadly enough to include consensual sex (when it occurs in exchange for money). Now Ohio is poised to classify merely talking about consensual sex, even when no money is involved, as a species of sexual slavery.
The Ohio Senate is expected to take up the bill after returning from its summer break.
Source: http://reason.com/blog/2013/06/28/hookup-shocker-the-sex-is-legal-but-talk
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Most Influential Ad Execs On Twitter - Business Insider
When we asked our friends at PeekAnalytics to tell us who the most influential ad execs on Twitter are, we expected to get back a list of the usual suspects. You know, the most famous CEOs at the biggest agencies, plus Seth Godin, Lee Clow's Beard, and perhaps KBS+'s Lori Senecal, who once bought promoted tweets for herself.
In fact, none of the huge names of advertising are influential on Twitter, according to PeekAnalytics. The company ranked our Twitterers by "social pull" as opposed to mere total followers. Social pull is a "metric which takes into account not only the quantity of each audience's connections across 60 social networking sites, but also how active and connected, and therefore influential, those connections are."
One of the names on our list has an amazing 313,000 followers. Most have more than 10,000, with many in the mid five figures.
We learned that to be successful on Twitter as an ad exec, you have to be positive and upbeat. No Debbie Downers here.
The way to get retweeted is to give advice, and offer a lot of aphorisms about success in business.
The medium also lends itself to specialists like John Sonnhalter. He has nearly 14,000 followers on Twitter but few on Madison Avenue will recognize his name ? he specializes in ads and sales for the construction business.
Source: http://www.businessinsider.com/most-influential-ad-execs-on-twitter-2013-6
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Friday, June 28, 2013
James Woods Shows Off New Young Girlfriend!
The actor is dating a new lady! Plus, check out more pics of your favorite stars on the scene!
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Adobe Dreamweaver CC
Adobe could have rested on its laurels when updating Dreamweaver to its latest incarnation in the subscription-based Creative Cloud service as Dreamweaver CC. In its previous incarnation as Dreamweaver CS6, part of Adobe's Creative Suite 6, Adobe's advanced website editor already had little or no serious competition as a tool for creating and maintaining today's multiplatform websites. Dreamweaver CS6, for example, introduced ready-to-use "fluid grid" Web layouts that use CSS to reshape webpages automatically according to the screen size, making it easy to build a single site use with phones, tablets, and desktops without the complex CSS hand-coding previously required.
The new Dreamweaver CC enhances the fluid-grid feature by supporting HTML5 structural elements such as Sections and Articles. It also adds an equally effort-saving tool, a new CSS Designer that uses an interactive graphic interface for modifying CSS properties like shadows and curved corners, so you only need to click and drag to modify complex CSS code while seeing the results in real-time. Full support for Web-based fonts?downloaded from Adobe's servers while the browser loads a page?makes it easy to create eye-catching designs. Also, like the rest of the Creative Cloud suite, Dreamweaver also gets a simplified and more easily customizable interface, and works identically under both Windows and OS X.
Pro and Semi-Pro
Dreamweaver is a professional-level tool that's worth having?if you can afford it?even if you're a non-professional. First-time Dreamweaver users may be intimidated by the multitude of menus and property panels in the default layout, but it soon becomes clear how to use these to get quick access to advanced controls over CSS elements, or to switch quickly between displays that show how a webpage will look when printed or when displayed on different size screens. Advanced Web designers can click on a menu of JavaScript-based UI widgets into their code to create pop-up dialogs, date-pickers, accordion-style menus, and everything else in the current repertory of UI effects. But even less-advanced users can create flexible HTML5-compliant sites that look good on any platform.
Start Weaving Dreams
Starting from either a blank page or sample layout, you click on items in an Insert panel to add elements like templates (with editable and uneditable regions), multimedia (HTML5 or Flash), and standard HTML features. The default screen is split into a code pane and a WYSIWYG design pane, but you can choose one or the other, or make the design pane "Live" to view media content like video, or content that will be served up from a database when the page appears in a browser. One thing I admire about Dreamweaver is that it doesn't favor Adobe's proprietary technologies like Flash over open standards like HTML5 video, but gives equal support for both?and even provides a better-looking and more usable HTML5 video player than its built-in Flash player.
When you build a page with Dreamweaver's fluid grid feature, the app first creates a page that contains a grid of vertical columns that are visible in Dreamweaver but not when the page appears in a browser. By default, a page designed for phones fits into four of these invisible columns. When the same page is displayed on a tablet, it fills eight columns, and twelve columns when displayed on a desktop machine.
When you switch between screen sizes in Dreamweaver's editing window, the content of your site rearranges itself to fit the width that you specified for the specific type of screen, and you can use the CSS Designer panel to adjust the shape, size, and other properties of individual elements to suit the different screen sizes.
Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/4bSyIbqqINQ/0,2817,2421105,00.asp
Egypt: Opposition rejects Morsi's dialogue offer
CAIRO (AP) ? Egypt's main opposition coalition has rejected the Islamist president's offer for dialogue on reconciliation and says it insists on holding early presidential elections.
A statement by the National Salvation Front read by reform leader Mohamed ElBaradei said Mohammed Morsi's 2 ?-hour speech late Wednesday reflected a "clear inability" to acknowledge the difficult conditions in Egypt.
Morsi spoke ahead of opposition plans for street rallies on June 30 aimed at forcing him from office. He told his opponents to use elections not protests to try to change the government and counseled the military, which has warned it would intervene if violence breaks out, to focus on improving its capabilities and defending the nation.
Speaking Thursday, ElBaradei said "nothing will change our determination to go out on June 30 everywhere in Egypt."
Source: http://news.yahoo.com/egypt-opposition-rejects-morsis-dialogue-offer-175226402.html
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Salt and Pepper Spoon Shakers Give You Precisely Portioned Seasonings
Finally putting an end to the gag where someone unscrews the lid of a salt shaker, Jaemin Jaeminlee's Sogum HuchuHuchu is a radical re-thinking of how we season our food at the table. They still require a bit of shaking to get the spices out, but instead of dumping it directly onto your food, the salt and pepper spills into a small scoop. Using your fingers you're then able to select an exact amount of seasonings for your meal, while the unused bits can be returned to the shaker.
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Microsoft's Xbox 180 won't inhibit online-only games on the Xbox ...
Microsoft came out beating the drum for cloud services and restrictive online requirements when it announced the Xbox One at the end of May. Since then, Redmond has completely flip-flopped on its online requirements and used game restrictions, but the Xbox Live Cloud service hasn?t been harmed in the process. Even though the Xbox One won?t require you to connect to the internet, individual games on the platform most certainly will.
With the launch of the Xbox One, Microsoft will be making Xbox Live Cloud services available to game developers. ?Cloud? is obviously a very nebulous term used in marketing speak, but it has real benefits to both developers and gamers alike. Over 300,000 servers worldwide can be allocated dynamically in service of both multiplayer and single-player games. Sure, the Xbox Live Cloud can work as online storage for game assets, but it?s much more than that. By offering server-side computation as well, Microsoft?s ubiquitous cloud offering gives developers affordable tools that they just didn?t have in previous generations.
Jon Shiring, an engineer at Respawn Entertainment, took to his company?s blog to speak about the benefits of the Xbox Live Cloud. In detail, Shiring explains the problems that go along with having player-hosted game servers, and why having affordable dynamically scaling dedicated servers is a huge benefit for multiplayer games. Microsoft?s Azure-based Xbox Live Cloud allows developers like Respawn to improve AI, remove unfair player advantages, speed up matchmaking, and dedicate all resources on the local machine to improve the visuals and frame rate.
Since Respawn?s game Titanfall is effectively multiplayer-only, it requires an always-on internet connection. Despite the fact that Microsoft is publicly slinking away from internet requirements, some games on the Xbox One will still demand an internet connection to function at all. Obviously, the benefits Microsoft originally laid out for its Xbox Live Cloud service can and will thrive in this ecosystem.
Single-player games will definitely benefit as well. Computation-intensive sections of a game, like large dynamic backgrounds, can be handled in the cloud while latency-sensitive portions like aiming and damage calculations can happen in real-time on the console itself. For example, a developer could use the cloud to render an accurate depiction of what the night sky looks like where you live while the console itself has more resources freed up to improve moment-to-moment gameplay.
Fundamentally, the fact that Microsoft is offering cheap access to cloud storage and computing for all participating developers is a win for everyone. This initiative lets developers expand game worlds, takes a substantial load off of the Xbox One?s CPU and GPU, and has the added benefit (for Microsoft) of keeping most people connected to the internet for all of these features. The Xbox One will need an internet connection for a nontrivial amount of games, and that?s okay. Provided the gaming industry learned its lesson about failing gracefully from the SimCity debacle, the Xbox One could have a significant edge over PS4 if the Xbox Live Cloud delivers on its promises.
Now read: Microsoft reverses Xbox One always-on policies, but removes positive features in process
[Image credit: Microsoft & Respawn]
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Thursday, June 27, 2013
Think You Can?t Quit Your Job? These People Did.
Some of us go through our professional lives wondering if we?re in the right line of work or if there?s something else we could be doing that would make us happier. Musing about a career change or other life pivot can be a potent source of motivation, yet most of us never act on these impulses. Those who do follow through often engineer second acts that are game changers.?
For our special series on Second Acts, we asked readers to share their stories of starting over. Slate?s David Plotz discusses some of his favorites in the video above.
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Friday, June 21, 2013
Help Your Home With Some Home Improvement - Home Reno
You may think that they could never improve your own home. Know that there are lot of projects that someone who is inexperienced can easily master. Home improvements are valuable for a number of reasons, and the article below provides you with some of the things you need to know to be successful.
If you are considering major structural modifications to your floor plan, then employ an architect to draw up your plans. If you don?t have the expertise to back up your vision, your plans are most likely going to be dysfunctional from the start. A professional designer can come up with concrete plans that are viable and that conform to local building codes.
There are two easy things you can do if you would like your ceiling to look higher than it truly is. Add a funky lamp to your room or paint your walls in more than one color. This will make a optical illusion that makes the room seem bigger. Your eyes focus on the lines and make the ceilings look like they are higher.
You can make a huge positive difference in the appearance of a room by installing a new floor in it. A reliable contractor can lay down a new carpet, hardwood or laminate floor in no time at all or, if you are so inclined, look for supplies a a local retailer and do the project yourself.
Use a wet sponge on your drywall installation. Rather than sanding the seams in your drywall, sponge them. A sponge can smooth the seams as effectively as a sander. With the sponge, though, you?ll avoid getting all that drywall dust all over your house.
Apply striping to the walls prior to doing a paneling installation. No matter how careful you are when installing paneling, the old wall still peeks through. To minimize this issue, measure and mark where each panel will meet before installing. Use paint that matches the paneling.
When remodeling the tile floors, consider more high-tech options such as tiles that radiate heat. These are a special form-factor, which allows electricity to create power through a heating element and warm the ground beneath your toes. Radiant heat tiles are easy to install. This makes it a project you can add on whether you are hiring someone or doing it yourself. Either way, you will be thankful that you chose radiant heat tiles on the first cold day of the season.
Purchase transparent plastic bins with lids to help organize your garage properly. Get labels for these boxes, and be sure that they can stack together. This will not only make your garage nice and tidy, but it will also keep pests out of your stuff.
Do not get rid of your doors because they look dirty. You should instead remove the door and then sand down the wood. Then, find an oil that you can paint over the door with. Buy fancier doorknobs if you want to give your door a new feel.
It is possible to give your kitchen a better, more current look without becoming bankrupt in the process. Is your refrigerator still working good? Do you like stainless steel Consider buying appliance spray paint to color your appliances in any hue you can imagine. This can easily change the feel of your kitchen in no more than a day.
Anyone can work on their house if they really try and are dedicated to the process. Now that you have read these tips, you hopefully have gained some confidence in yourself and are ready to tackle your own home improvement projects. Seeing the results of your own handiwork will give you a feeling of pride and accomplishment.
Source: http://www.renmenbi.com/help-your-home-with-some-home-improvement/
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Tuesday, May 7, 2013
Older adults' memory lapses linked to problems processing everyday events
May 7, 2013 ? Some memory problems common to older adults may stem from an inability to segment daily life into discrete experiences, according to a new study published in Psychological Science, a journal of the Association for Psychological Science.
The study suggests that problems processing everyday events may be the result of age-related atrophy to a part of the brain called the medial temporal lobe (MTL).
"When you think back on what you did yesterday, you don't just press 'play' and watch a continuous stream of 24 hours," says psychological scientist Heather Bailey of Washington University in St. Louis, who led the study. "Your brain naturally chunks the events in your day into discrete parts."
Bailey and her colleagues hypothesized that older adults may have difficulty with memory for everyday events because they don't segment them in the same way as they're happening.
In the study, older adults -- some of whom had Alzheimer's type dementia -- watched short movies of people doing everyday tasks, such as a woman making breakfast or a man building a Lego ship. They were told to separate the movie into chunks by pressing a button whenever they thought one part of the activity in the movie was ending and a new part was beginning.
Afterward, the researchers asked the older adults to recall what happened in the movie. They also measured the size of the older adults' MTL using structural magnetic resonance imaging (MRI).
"The older adults who showed atrophy in the MTL weren't as good at remembering the everyday activities, and they weren't as good at segmenting and chunking the events as they were happening," says Bailey. "MTL size accounted for a huge portion of the relationship that we saw between participants' ability to segment and their memory for the events."
These findings suggest that the characteristic forgetfulness of the aging mind isn't just a problem with recalling memories later, but also with how we view and chunk events as they unfold, a process that depends on MTL functioning.
In light of this, focusing on how to better form new memories may be one way to improve older adults' memory for everyday events, even for those adults who have clinical diagnoses like Alzheimer's.
"Alzheimer's disease attacks the MTL in the early stages of the disease," says Bailey. "But even with MTL atrophy you may be able to train people to chunk better, which might help them to remember their everyday activities better, too."
As part of their future research, Bailey and colleagues hope to further investigate the link between event perception and memory to see if they can combat memory impairments in older adults.
Co-authors on the research include Jeffrey M. Zacks and Denise Head of Washington University in St. Louis; David Z. Hambrick and Rose T. Zacks of Michigan State University; Christopher A. Kurby and Jesse Q. Sargent of Francis Marion University.
This research was supported by National Institutes of Health Grants R01 AG031150 and F32 AG039162; and National Institute on Aging Grants P50 AG05681, P01 AG03991, and P01 AG26276.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/GP6vuPl5U2k/130507134643.htm
Why Baby's Hungry Cry Tugs at Women (But Not Men)
The idea that women are hard-wired to respond to babies is supported in a small new brain scan study from Italy.
Women in the study who listened to the sounds of a baby crying in hunger showed a change in activity in certain brain regions, but men showed no change.
The study included nine men and nine women, some of whom were parents. Most participants were in their 30s. Researchers at the University of Trento asked participants to let their minds wander, and then played a recording of about 15 minutes of white noise, interrupted with periods of silence and the sounds of a hungry infant crying.
In women's brains, there was a decrease in activity in two areas known to be active during mind wandering ? the dorsal medial prefrontal and posterior cingulate areas. By contrast, these regions in men's brains remained active when they heard the baby's cries, according the study.
The study shows that "women interrupt mind wandering when exposed to the sounds of infant hunger cries, whereas men carry on without interruption," the researchers wrote.
The brain patterns were not different between parents and nonparents in the study, the researchers said. This suggests that women may be predisposed to care for infants other than their own, the researchers said, though more study is needed to see whether this idea is held up.
Previous studies have shown that women are more likely than men to say that hearing an infant cry evokes feelings of sympathy and caregiving, while men are more likely to say that crying evokes irritation and anger.
Other work has shown that mothers' suffering from postpartum depression have muted brain activity patterns when they hear their baby cry, compared with nondepressed women.
The study was published in the February issue of the journal Neuroreport.
Pass it on: Hungry baby's cry affects the mother's brain, and evokes sympathy and caring.
Follow Karen Rowan?@karenjrowan. Follow MyHealthNewsDaily?@MyHealth_MHND, Facebook?&?Google+. Originally published on MyHealthNewsDaily.
Copyright 2013 MyHealthNewsDaily, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/why-babys-hungry-cry-tugs-women-not-men-171814583.html
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New Samsung Galaxy S4 cases that won?t make you broke
We’ve all been there… We spend all of our “fun” money on a shiny new phone and then realize we don’t have enough money left to buy a case to keep it looking shiny and new. The SUPCASE Unicorn Beetle Series Premium Hybrid Protective Case may have a crazy name, but it doesn’t have a [...]
Source: http://the-gadgeteer.com/2013/05/07/new-samsung-galaxy-s4-case-that-wont-make-you-broke/
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Tactus And Synaptics Create A Reference Tablet For OEMs With An Amazing, Disappearing Keyboard
One of the most impressive things we happened upon at CES this year was the Tactus keyboard, a special fluid-filled layer that could be baked into a tablet or smartphone to provide users with a physical keyboard that could recede back into the screen when it wasn?t needed. Since then the company has been flying under the radar, but it turns out Tactus has been hard at work on a prototype device with help from a prominent player in the touch interaction space. Tactus confirmed to TechCrunch that it has partnered with touch panel experts at Synaptics to create a reference device ? a 7-inch Android-powered tablet ? that it will begin shopping around to OEMs and carriers at the end of June.Source: http://feedproxy.google.com/~r/Techcrunch/~3/LgLhb6JPUEk/
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Monday, May 6, 2013
1 German soldier killed, 1 wounded in Afghanistan
BERLIN (AP) ? Insurgents in northern Afghanistan have killed a German special forces soldier and wounded a second, the German defense minister said Sunday. The fatality marks the first death in combat of a member of Germany's special forces in Afghanistan.
The soldiers were accompanying an Afghan-led military operation on Saturday when insurgents opened fire at a river crossing in Baghlan province, using fire arms and rocket-propelled grenades.
The troops called in air support but the special forces soldier was fatally shot later when exploring the airstrike's damage, Defense Minister Thomas de Maiziere said. The wounded special forces soldier's condition was not life-threatening, he added.
The 1,000-strong special forces are considered to be the German military's elite force, similar to U.S. Navy SEALs.
Several insurgents are believed to have been killed in the fighting some 26 kilometers (16 miles) north of the German base near the city of Baghlan, the military said. There was no immediate information on casualties among the Afghan troops, it added.
The NATO-led coalition forces in Kabul said late Saturday that one international service member had been killed in the north but provided no details.
Germany's 4,000-odd troops in Afghanistan are in charge of much of the country's north, which tends to be relatively calm compared to the more volatile southern or eastern areas.
Also Saturday, seven U.S. soldiers were killed in various attacks. Five U.S. troops were killed by a roadside bomb in the south, while two others died as a soldier with the Afghan National Army turned his weapon on coalition troops in the west.
"This was a bitter, a bloody day in Afghanistan and we won't forget it," de Maiziere told journalists in Berlin.
Germany is the third-largest international troop contributor in Afghanistan, where a total of 35 German soldiers have been killed in attacks or combat since 2002. The mission is generally unpopular in Germany but is supported by most political parties.
Source: http://news.yahoo.com/1-german-soldier-killed-1-wounded-afghanistan-115528798.html
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Improving materials that convert heat to electricity and vice-versa: Turning waste heat into electricity
May 5, 2013 ? Thermoelectric materials can be used to turn waste heat into electricity or to provide refrigeration without any liquid coolants, and a research team from the University of Michigan has found a way to nearly double the efficiency of a particular class of them that's made with organic semiconductors.
Organic semiconductors are carbon-rich compounds that are relatively cheap, abundant, lightweight and tough. But they haven't traditionally been considered candidate thermoelectric materials because they have been inefficient in carrying out the essential heat-to-electricity conversion process.
Today's most efficient thermoelectric materials are made of relatively rare inorganic semiconductors such as bismuth, tellurium and selenium that are expensive, brittle and often toxic. Still, they manage to convert heat into electricity more than four times as efficiently as the organic semiconductors created to date.
This greater efficiency is reflected in a metric known by researchers as the thermoelectric "figure of merit." This metric is approximately 1 near room temperature for state-of-the-art inorganic thermoelectric materials, but only 0.25 for organic semiconductors.
U-M researchers improved upon the state-of-the-art in organic semiconductors by nearly 70 percent, achieving a figure-of-merit of 0.42 in a compound known as PEDOT:PSS.
"That's about half as efficient as current inorganic semiconductors," said project leader Kevin Pipe, an associate professor of mechanical engineering as well as electrical engineering and computer science. Pipe is a co-author of a paper on the research published in Nature Materials on May 5, 2013.
PEDOT:PSS is a mixture of two polymers: the conjugated polymer PEDOT and the polyelectrolyte PSS. It has previously been used as a transparent electrode for devices such as organic LEDs and solar cells, as well as an antistatic agent for materials such as photographic films.
One of the ways scientists and engineers increase a material's capacity for conducting electricity is to add impurities to it in a process known as doping. When these added ingredients, called dopants, bond to the host material, they give it an electrical carrier. Each of these additional carriers enhances the material's electrical conductivity.
In PEDOT doped by PSS, however, only small fraction of the PSS molecules actually bond to the host PEDOT; the rest of the PSS molecules do not become ionized and are inactive. The researchers found that these excess PSS molecules dramatically inhibit both the electrical conductivity and thermoelectric performance of the material.
"The trouble is that the inactive PSS molecules push the PEDOT molecules further apart, making it harder for electrons to jump between PEDOT molecules," Pipe said. "While ionized PSS molecules improve electrical conductivity, non-ionized PSS molecules reduce it."
To improve its thermoelectric efficiency, the researchers restructured the material at the nanoscale. Pipe and his team figured out how to use certain solvents to remove some of these non-ionized PSS dopant molecules from the mixture, leading to large increases in both the electrical conductivity and the thermoelectric energy conversion efficiency.
This particular organic thermoelectric material would be effective at temperatures up to about 250 degrees Fahrenheit.
"Eventually this technology could allow us to create a flexible sheet -- think of Saran Wrap -- that can be rolled out or wrapped around a hot object to generate electricity or provide cooling," Pipe said.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/N7MPWBy3_MQ/130505145941.htm
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Assembly of a protein degradation machine could lead to treatments in cancer, neurological diseases
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 5-May-2013[ | E-mail |
Share ] Contact: Jeroen Roelofs
jroelofs@k-state.edu
785-532-3969
Kansas State University
MANHATTAN, Kan. -- Kansas State University scientists helped discover new details about an intricate process in cells. Their finding may advance treatments for cancer and neurological diseases.
Kansas State University researchers Jeroen Roelofs, assistant professor, and Chingakham Ranjit Singh, research assistant professor -- both in the Division of Biology -- led part of the study. Both also are research affiliates with the university's Johnson Cancer Research Center. They worked with colleagues at Harvard Medical School, the University of California-San Francisco and the University of Kansas. The scientific journal Nature recently published the team's observations, titled "Reconfiguration of the proteasome during chaperone-mediated assembly."
The research focused on proteasomes, protein complexes inside the cells of humans and other organisms that help keep the cells healthy.
"The proteasome is a large, molecular machine in the cell that degrades other proteins," Roelofs said. "It's important for protein quality control as well as for the cell's ability quickly remove specific proteins, thereby ensuring the cell's health and proper function."
The goal was to better understand how the various particles inside proteasomes work together to make the proteasomes function -- think the gears and components needed, and in what order, to build a working machine. Scientists believe that disruption of two key particles -- and consequently a proteasome's ability to work correctly -- has implications for cancers as well as various neurological degenerative diseases, such as Parkinson's and Huntington's diseases.
The Nature study built on research that Roelofs made as a postdoctoral research fellow at Harvard Medical School in 2009. He found that proteins called chaperones play a key role in the assembly process of two particles that when connected, gives proteasomes the ability to scrub unwanted proteins from cells. Chaperones act as a foreman for the two particles.
One of the findings in the new study is that in addition to acting as a molecular foreman for the two particles, chaperones also control when those two particles come together. Similarly, the scientists found more about the two particles.
The core particle has seven pockets while the regulatory particle has six tails that tuck into those pockets. When docked together, they turn on the proteasome's functionality.
"In the assembly process there is only one tail that actually determines how the core particle and regulatory particle bind together," Roelofs said. "That's surprising because there are six tails, but only one is needed to give specificity, and the docking into the pocket is controlled by the chaperone."
Roelofs believes that the findings may reveal new targets for anticancer drugs, as a chaperone in the human genes is involved in liver cancer. The proteasome inhibitor Bortezomib is used in the treatment of current cancers. Additionally, the information may advance cancer and neurological research by giving scientists new pathways to study and manipulate.
"This is pretty basic research," Roelofs said. "Understanding the basic mechanics can often lead to new pathways for improvement, which is essential when it comes to human health."
Scientists made the findings through a combination of techniques, including Cryo-electron microscopy, X-ray crystallography, yeast genetics, biochemical reconstitution assays and proteasome activity measurements. These techniques helped researchers observe the submicroscopic tails and complex tail-to-pocket binding process, as well as study the role of the chaperones in the core and regulatory particle process.
###
The study was largely funded by the Centers of Biomedical Research Excellence Protein Structure and Function, or COBRE-psf, support center at the University of Kansas -- a multidisciplinary, biomedical research program funded by the National Institute of Health; the Johnson Cancer Research Center at Kansas State University; and the Kansas IDeA Network of Biomedical Research Excellence, or K-INBRE.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 5-May-2013[ | E-mail |
Share ] Contact: Jeroen Roelofs
jroelofs@k-state.edu
785-532-3969
Kansas State University
MANHATTAN, Kan. -- Kansas State University scientists helped discover new details about an intricate process in cells. Their finding may advance treatments for cancer and neurological diseases.
Kansas State University researchers Jeroen Roelofs, assistant professor, and Chingakham Ranjit Singh, research assistant professor -- both in the Division of Biology -- led part of the study. Both also are research affiliates with the university's Johnson Cancer Research Center. They worked with colleagues at Harvard Medical School, the University of California-San Francisco and the University of Kansas. The scientific journal Nature recently published the team's observations, titled "Reconfiguration of the proteasome during chaperone-mediated assembly."
The research focused on proteasomes, protein complexes inside the cells of humans and other organisms that help keep the cells healthy.
"The proteasome is a large, molecular machine in the cell that degrades other proteins," Roelofs said. "It's important for protein quality control as well as for the cell's ability quickly remove specific proteins, thereby ensuring the cell's health and proper function."
The goal was to better understand how the various particles inside proteasomes work together to make the proteasomes function -- think the gears and components needed, and in what order, to build a working machine. Scientists believe that disruption of two key particles -- and consequently a proteasome's ability to work correctly -- has implications for cancers as well as various neurological degenerative diseases, such as Parkinson's and Huntington's diseases.
The Nature study built on research that Roelofs made as a postdoctoral research fellow at Harvard Medical School in 2009. He found that proteins called chaperones play a key role in the assembly process of two particles that when connected, gives proteasomes the ability to scrub unwanted proteins from cells. Chaperones act as a foreman for the two particles.
One of the findings in the new study is that in addition to acting as a molecular foreman for the two particles, chaperones also control when those two particles come together. Similarly, the scientists found more about the two particles.
The core particle has seven pockets while the regulatory particle has six tails that tuck into those pockets. When docked together, they turn on the proteasome's functionality.
"In the assembly process there is only one tail that actually determines how the core particle and regulatory particle bind together," Roelofs said. "That's surprising because there are six tails, but only one is needed to give specificity, and the docking into the pocket is controlled by the chaperone."
Roelofs believes that the findings may reveal new targets for anticancer drugs, as a chaperone in the human genes is involved in liver cancer. The proteasome inhibitor Bortezomib is used in the treatment of current cancers. Additionally, the information may advance cancer and neurological research by giving scientists new pathways to study and manipulate.
"This is pretty basic research," Roelofs said. "Understanding the basic mechanics can often lead to new pathways for improvement, which is essential when it comes to human health."
Scientists made the findings through a combination of techniques, including Cryo-electron microscopy, X-ray crystallography, yeast genetics, biochemical reconstitution assays and proteasome activity measurements. These techniques helped researchers observe the submicroscopic tails and complex tail-to-pocket binding process, as well as study the role of the chaperones in the core and regulatory particle process.
###
The study was largely funded by the Centers of Biomedical Research Excellence Protein Structure and Function, or COBRE-psf, support center at the University of Kansas -- a multidisciplinary, biomedical research program funded by the National Institute of Health; the Johnson Cancer Research Center at Kansas State University; and the Kansas IDeA Network of Biomedical Research Excellence, or K-INBRE.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-05/ksu-aoa050313.php
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